Study data regarding the prognostic implications of fascicular blocks, incomplete bundle branch blocks and the R-R’ pattern in either of the leads V1 or V2 to predict HF is practically non-existent. Non-specific IVCD has previously been associated with cardiovascular (CV) mortality and sudden cardiac death, , but the progression to HF has not been extensively studied in patients without overt cardiac disease. Studies conducted in recent years have evaluated the role of LBBB in inducing left ventricular systolic decline, , while RBBB should play no significant negative role in this aspect. IVCDs are frequent in patients with structural heart disease (SHD), including valvular heart diseases and cardiomyopathies, but no prior prospective population studies have related IVCDs to novel SHD in subjects without known heart disease. Literature assessing the role of IVCDs as risk markers for the development of HF is scarce and has presented conflicting results, and has evaluated only selected bundle branch block categories, ,. For timely initiation of therapy, subjects with high-risk of developing HF ought to be identified. Mortality rates remain high in symptomatic patients with advanced HF and reduced ejection fraction in spite of improvements in medical therapy and effective utilization of cardiac resynchronization therapy.
Left bundle branch block (LBBB), right bundle branch block (RBBB), and non-specific IVCD were associated with increased mortality especially in patients with myocardial infarction (MI), , and heart failure (HF),. Intraventricular conduction delays (IVCDs) have been associated with impaired prognosis in patients with known cardiac disease.
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